Earlier studies have reported that WT-AT1 displays only a moderate constitutive activity (Miura et al

Earlier studies have reported that WT-AT1 displays only a moderate constitutive activity (Miura et al., 2006, 2008). attenuates an inverse agonistic effect of four biphenyl-tetrazole ARBs through changes in specific ligand-receptor relationships. In the ground state, tight relationships of four ARBs with a set of residues (Ser109TM3, Phe182ECL2, Gln257TM6, Tyr292TM7, and Asn295TM7) results in potent…